Although I'm not as much of a movie junkie as the rest of the people I associate with, there's a handful of films out there that are relatively life-altering.

The Garden State
"So, what do we do now?"


This film single-handedly got me into offbeat cinema; while The Garden State isn't really that weird, it takes a certain kind of mentality to really love. Besides, the ending is one of the most beautiful endings in film history (save for, quite possibly, Casablanca).
The Corporation
"We created something that's gonna destroy us."


An activist documentary at its' finest. A fascinating look at corporate culture and its' dominance in society today. Includes worrying affirmation that some CEO's in this world really don't care about the environment.
Little Miss Sunshine
"Do what you love. Fuck everything else."


I've always been a fan of anything that Steve Carrell works on, but this really does take the cake. A fabulously dysfunctional family, an unconventionally beautiful little girl in a beauty contest, and a road trip to California all combine for the best movie of 2006. The inclusion of Sufjan Stevens on the soundtrack certainly doesn't hurt, either.
Fight Club
"You met me at a very strange time in my life."


I didn't see this movie until the summer of 2006 (seven years too late, probably), but I'm thankful I finally remedied that situation. The apocalyptically romantic ending with The Pixies playing in the background just floors me every time.
Brick
"Maybe I'll just sit here and bleed at you."


And I thought film noir was dead. Director Rian Johnson puts together a young cast that delivers a modernized twist on the old genre. Set in a high school in California in present day, the characters rattle off film noir lingo like it's all they've been watching since leaving the womb. Dark, intense, with a couple of the most visually hysterical scenes you'll ever see.
Diarios de Motocicleta
"This isn't a tale of heroic feats."


Better known in the English language as The Motorcycle Diaries, the film is a view of the life of Ché Guevara before becoming an inspirational revolutionary. His progession from someone who wanted to get in touch with his home continent to someone that believed South America was worth fighting for and maintaining with socialism is truly touching. Also, the soundtrack by Gustavo Santaolalla contains some jaw-dropping guitar work.